肺作为造血祖细胞的龛位。
Lung as a Niche for Hematopoietic Progenitors.
机构信息
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
出版信息
Stem Cell Rev Rep. 2017 Oct;13(5):567-574. doi: 10.1007/s12015-017-9747-z.
Abstract
Platelets are released from megakaryocytes. The bone marrow has been proposed to be the major site where this process occurs. Lefrançais et al. (2017) using state-of-the-art techniques including two-photon microscopy, in vivo lineage-tracing technologies, and sophisticated lung transplants reveal that the lung is also a primary site for platelet biogenesis. Strikingly, lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia. This study also shows that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs. This work brings a novel unexpected role for the lung as a niche for hematopoiesis. The emerging knowledge from this research may be important for the treatment of several disorders.
摘要
血小板由巨核细胞释放。骨髓被认为是这个过程发生的主要部位。Lefrançais 等人（2017 年）使用最先进的技术，包括双光子显微镜、体内谱系追踪技术和复杂的肺移植，揭示了肺也是血小板生成的主要部位。引人注目的是，肺巨核细胞可以在血小板减少症小鼠的血液中完全重建血小板计数。这项研究还表明，造血祖细胞在肺部存在，具有在照射后重新填充骨髓的能力。这项工作为肺作为造血龛位带来了一个新的意想不到的作用。这项研究的新发现可能对几种疾病的治疗很重要。
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