Thomas Shaji, Singh V Dal, Vaithilingam Yuvaraj, Thayil Sumeeth Cyriac, Kothari Rohit
People's College of Dental Sciences & Research Centre, Bhopal, India.
Oral Maxillofac Surg. 2012 Jun;16(2):233-6. doi: 10.1007/s10006-011-0292-7. Epub 2011 Sep 28.
Rhinocerebral mucormycosis (RCM) is a rare, fulminating opportunistic fungal infection caused by a fungus of order Mucorales. These fungi are ubiquitus, subsisting on decaying vegetation and diverse organic material. Although fungi and spores of Mucorales show minimal intrinsic pathogenicity towards normal person, they can initiate aggressive and fulminating infection in immunocompromised host. Since RCM occurs infrequently, it may pose a diagnostic and therapeutic dilemma for those who are not familiar with its clinical presentation.
We present a patient with classical presentation of RCM involving paranasal sinuses, orbit, and cranial base who was treated by combination of aggressive surgical and medical therapy.
The purpose of this paper is to draw attention to the clinical presentation and pathogenesis of RCM and to emphasize need for high index of suspicion in diagnosis and treatment.
鼻脑型毛霉菌病（RCM）是一种由毛霉目真菌引起的罕见的、暴发性机会性真菌感染。这些真菌无处不在，寄生于腐烂的植被和各种有机物质上。尽管毛霉目真菌和孢子对正常人的内在致病性极小，但它们可在免疫功能低下的宿主中引发侵袭性和暴发性感染。由于RCM很少发生，对于不熟悉其临床表现的人来说，可能会带来诊断和治疗上的困境。
我们报告一名具有RCM典型表现的患者，累及鼻窦、眼眶和颅底，接受了积极的手术和药物联合治疗。
本文旨在引起对RCM临床表现和发病机制的关注，并强调在诊断和治疗中需要高度怀疑。
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