Ootaki Yoshio, Kamohara Keiji, Akiyama Masatoshi, Zahr Firas, Kopcak Michael W, Dessoffy Raymond, Massiello Alex, Horvath David, Chen Ji-Feng, Benefit Stephen, Golding Leonard A R, Fukamachi Kiyotaka
Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
ASAIO J. 2005 Nov-Dec;51(6):739-42. doi: 10.1097/01.mat.0000187399.46756.fc.
Despite the increasing use of left ventricular assist devices for patients with end-stage congestive heart failure, no implantable, centrifugal right ventricular assist devices (RVADs) are available for those patients with significant right ventricular failure. The DexAide RVAD was developed to provide an implantable RVAD option to surgeons. The aim of this study was to evaluate pump performance in an acute in vivo model. The DexAide RVAD, developed as a modified CorAide left ventricular assist device, was implanted between the right ventricle and the pulmonary artery in four healthy calves. Pump speed was varied from 1800 rpm to 3600 rpm. RVAD performance was analyzed acutely at baseline and under conditions of low circulating volume, high contractility, high pulmonary arterial pressure, vasodilation, and low contractility. Pump flow was well maintained even under conditions of high pulmonary arterial pressure and vasodilation, with the exception of low circulating volume. Under all conditions, pulmonary arterial pressures were not affected by changing pump speed. The DexAide RVAD demonstrated acceptable hemodynamic characteristics for use as an implantable RVAD in the initial acute studies. Further studies are ongoing to examine the biocompatibility of the pump under chronic conditions.
尽管左心室辅助装置在终末期充血性心力衰竭患者中的使用越来越多，但对于那些有严重右心室衰竭的患者，尚无植入式离心右心室辅助装置（RVAD）可用。开发DexAide RVAD是为外科医生提供一种植入式RVAD选择。本研究的目的是在急性体内模型中评估该泵的性能。作为改良的CorAide左心室辅助装置开发的DexAide RVAD，被植入4只健康小牛的右心室和肺动脉之间。泵速在1800转/分钟至3600转/分钟之间变化。在基线以及低循环容量、高收缩性、高肺动脉压、血管舒张和低收缩性条件下，对RVAD性能进行了急性分析。除低循环容量外，即使在高肺动脉压和血管舒张条件下，泵流量也能得到很好的维持。在所有条件下，肺动脉压不受泵速变化的影响。在最初的急性研究中，DexAide RVAD表现出作为植入式RVAD可接受的血流动力学特征。正在进行进一步研究以检查该泵在慢性条件下的生物相容性。
