骨形态发生蛋白信号传导与脊椎动物神经系统发育

Bone morphogenetic protein signalling and vertebrate nervous system development.

作者信息

Liu Aimin, Niswander Lee A

机构信息

Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Mailstop 8322, P.O. Box 6511, Aurora, Colorado 80045, USA.

出版信息

Nat Rev Neurosci. 2005 Dec;6(12):945-54. doi: 10.1038/nrn1805.

DOI:10.1038/nrn1805

PMID:16340955

Abstract

Transforming growth factor-beta (TGFbeta) signalling, particularly signalling from the bone morphogenetic protein (BMP) members of this protein family, is crucial for the development of both the central and peripheral nervous systems in vertebrates. Experimental embryology and genetics performed in a range of organisms are providing insights into how BMPs establish the neural tissue and control the types and numbers of neurons formed. These studies also highlight the interactions between different developmental signals that are necessary to form a functional nervous system. The challenges ahead will be to uncover functions of TGFbeta signalling in later stages of CNS development, as well as to determine possible associations with neurological diseases.

摘要

转化生长因子-β（TGFβ）信号传导，尤其是该蛋白家族中骨形态发生蛋白（BMP）成员的信号传导，对于脊椎动物中枢神经系统和周围神经系统的发育至关重要。在一系列生物体中进行的实验胚胎学和遗传学研究正在为BMP如何建立神经组织以及控制所形成神经元的类型和数量提供见解。这些研究还强调了形成功能性神经系统所需的不同发育信号之间的相互作用。未来的挑战将是揭示TGFβ信号传导在中枢神经系统发育后期的功能，以及确定与神经疾病的可能关联。