Louvi Angeliki, Artavanis-Tsakonas Spyros
Department of Neurosurgery, Yale University School of Medicine, P.O. Box 208082, New Haven, Connecticut 06520-8082, USA.
Nat Rev Neurosci. 2006 Feb;7(2):93-102. doi: 10.1038/nrn1847.
Signals through the Notch receptors are used throughout development to control cellular fate choices. Loss- and gain-of-function studies revealed both the pleiotropic action of the Notch signalling pathway in development and the potential of Notch signals as tools to influence the developmental path of undifferentiated cells. As we review here, Notch signalling affects the development of the nervous system at many different levels. Understanding the complex genetic circuitry that allows Notch signals to affect specific cell fates in a context-specific manner defines the next challenge, especially as such an understanding might have important implications for regenerative medicine.
在整个发育过程中，通过Notch受体的信号用于控制细胞命运的选择。功能丧失和功能获得研究揭示了Notch信号通路在发育中的多效性作用，以及Notch信号作为影响未分化细胞发育路径工具的潜力。正如我们在此所综述的，Notch信号在许多不同水平上影响神经系统的发育。理解允许Notch信号以上下文特异性方式影响特定细胞命运的复杂遗传回路是下一个挑战，特别是因为这样的理解可能对再生医学具有重要意义。
