Jumean H G, Komorowski R, Mahvi D, Anderson T
Department of Medicine, Medical College of Wisconsin, Madison.
Gynecol Oncol. 1992 Jul;46(1):111-4. doi: 10.1016/0090-8258(92)90206-x.
A 30-year-old female was found to have a malignant immature teratoma of the ovary 14 years ago. This was treated with surgery followed by chemotherapy. Two years later, hepatic metastasis was discovered and treated with different multiple-agent chemotherapy, resulting in transformation or evolution into a mature teratoma form of disease. Twelve years later, this disease underwent malignant degeneration and transformed into a metastatic adenocarcinoma. This case report illustrates that malignant ovarian immature teratoma, teratocarcinoma, like its testicular counterpart, can evolve or differentiate into an apparently benign form of disease, but ultimately leads to death due to subsequent malignant transformation into new forms of malignancy arising from any of the three primordial germ cell layers.
一名30岁女性14年前被发现患有卵巢恶性未成熟畸胎瘤。接受了手术及后续化疗。两年后，发现肝转移，接受了不同的多药化疗，结果疾病转变或演变成成熟畸胎瘤形式。12年后，该疾病发生恶性退变，转变为转移性腺癌。本病例报告表明，恶性卵巢未成熟畸胎瘤、畸胎癌，与其睾丸对应物一样，可演变成或分化为明显良性的疾病形式，但最终会因随后恶性转变为源自三个原始生殖细胞层中任何一层的新恶性形式而导致死亡。
