Kajo Karol, Masák Ladislav, Sorkovská Dagmar, Vallová Miroslava, Kajo Michal, Macháleková Katarína, Heľpianská Lýdia
Cesk Patol. 2013 Oct;49(4):141-5.
Somatic malignant transformation in mature cystic teratoma is a rare phenomenon of a malignancy of differentiated tissue structures of any stem line. The authors present a case of a 38-year-old female with mature cystic teratoma of both ovaries and with mucinous adenocarcinoma arising from endodermal germ line in the right ovary, showing immunohistochemical features of non-intestinal differentiation. At the time of diagnosis the tumour metastasized to the pelvic and retroperitoneal lymph nodes. The patient was treated with three lines of chemotherapy and died after 15 months with signs of massive progression into the retroperitoneal, mediastinal and cervical lymph nodes, retroperitoneum, duodenal wall and peritoneal cavity. Somatic malignant transformation in mature cystic teratoma is associated with poor prognosis. The most important prognostic factor is tumour stage at the time of diagnosis.
成熟囊性畸胎瘤的体细胞恶性转化是任何干细胞系分化组织结构发生恶性肿瘤的罕见现象。作者报告了一例38岁女性，双侧卵巢均有成熟囊性畸胎瘤，右侧卵巢内胚层生殖系发生黏液腺癌，表现为非肠型分化的免疫组化特征。诊断时肿瘤已转移至盆腔和腹膜后淋巴结。该患者接受了三线化疗，15个月后死亡，出现向腹膜后、纵隔和颈部淋巴结、腹膜后、十二指肠壁和腹腔大量进展的迹象。成熟囊性畸胎瘤的体细胞恶性转化预后不良。最重要的预后因素是诊断时的肿瘤分期。
