Fischer S
Department of Pathology, Frederiksberg Hospital, Copenhagen, Denmark.
Gynecol Oncol. 1992 Jul;46(1):62-4. doi: 10.1016/0090-8258(92)90197-q.
Women who have not accepted an invitation by their own general practitioner to have a smear test, or for whom voluntary population screening projects are unavailable because of lack of public funds, may be at increased risk of malignant cervical changes. Such women may be offered self-testing by a cytopipette on the basis of the present analysis of abnormal cell counts and cell density on the cytological slides. As one link in a prophylactic study using the cytopipette, 107 women with abnormal cell findings were reinvited for simultaneous sampling by irrigation smear and by ordinary technique. The cytological findings indicate that the two methods are equal in recovery of abnormal epithelium, provided that the scanned quantity of cells is increased fourfold in the irrigation smear method, this quantity being distributed over two specimens each with double cell density and giving at least 1800 squamous epithelial cells per visual field (125:1) or a total of approximately 10(6) epithelial cells in each cytological specimen. Under these conditions the two sampling methods have the same predictive value.
那些未接受自己的全科医生进行涂片检查邀请的女性，或者因缺乏公共资金而无法参与自愿性人群筛查项目的女性，患宫颈恶性病变的风险可能会增加。基于目前对细胞学载玻片上异常细胞计数和细胞密度的分析，可为这类女性提供细胞吸管自检。作为使用细胞吸管进行预防性研究的一个环节，对107名细胞检查结果异常的女性再次进行邀请，让她们同时通过冲洗涂片法和常规技术进行取样。细胞学检查结果表明，只要冲洗涂片法中扫描的细胞数量增加四倍，且这些细胞分布在两个细胞密度加倍的样本中，每个视野至少有1800个鳞状上皮细胞（125:1），或者每个细胞学样本中共有约10⁶个上皮细胞，那么这两种方法在异常上皮细胞的检出率上是相同的。在这些条件下，两种取样方法具有相同的预测价值。
