Trillo A, Haust M D
Lab Invest. 1975 Jan;32(1):105-10.
Small, round, membrane-bound electron-dense bodies were observed in the smooth muscle cells and the intimal and medial intercellular spaces of arteries in the dog, rat, and pig under normal and various experimental conditions. These structures, referred to as granulovesicular bodies (GVB), measured from 0.2 to 0.5 mum. in diameter and contained an inner core of granular and vesicular subunits. The intercellular and extracellular forms of the GVB were structurally similar, and in the interstitial spaces they appeared to have a definite spatial relation to the elements of elastic tissue. The GVB were more numerous under experimental than under normal conditions. It is speculated that the GVB are secretory in nature, originating from the smooth muscle cells, and may play a role in the remodeling of arterial elastic fibers.
在正常及各种实验条件下，在狗、大鼠和猪的动脉平滑肌细胞以及内膜和中膜细胞间隙中观察到小的、圆形的、有膜包裹的电子致密体。这些结构被称为颗粒小泡体（GVB），直径为0.2至0.5微米，包含由颗粒和小泡亚基组成的内核。GVB的细胞内和细胞外形式在结构上相似，在间质空间中，它们似乎与弹性组织成分有明确的空间关系。实验条件下的GVB比正常条件下更多。据推测，GVB本质上是分泌性的，起源于平滑肌细胞，可能在动脉弹性纤维的重塑中起作用。
