监督性心血管训练计划对系统性红斑狼疮患者运动耐量、有氧能力和生活质量的影响。

Effects of supervised cardiovascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus.

作者信息

Carvalho Maria Rosenilda P de, Sato Emilia I, Tebexreni Antonio S, Heidecher Raquel T C, Schenkman Simone, Neto Turíbio L Barros

机构信息

Universidade Federal de São Paulo, Sao Paulo, Brazil.

出版信息

Arthritis Rheum. 2005 Dec 15;53(6):838-44. doi: 10.1002/art.21605.

DOI:10.1002/art.21605

PMID:16342102

Abstract

OBJECTIVE

To determine if supervised cardiovascular training improves exercise tolerance, aerobic capacity, depression, functional capacity, and quality of life in patients with systemic lupus erythematosus (SLE).

METHODS

Sixty women with SLE (ages 18-55 years) were evaluated using Short Form 36, visual analog scale for pain, scale for fatigue, Beck Depression Inventory, and Health Assessment Questionnaire (HAQ), and participated in a training protocol of incremental load on a treadmill with computed gas metabolic analysis. Maximum oxygen consumption (VO(2max)) and anaerobic threshold VO(2) were calculated with a SensorMedics Vmax29C analyzer (Sensor Medics, Yorba Linda, CA), and heart rate was measured by electrocardiogram. Patients were divided into 2 groups: a training group (41 patients) that participated in the supervised cardiovascular training program and a control group (19 patients) that did not participate in the program. All variables were analyzed at baseline and after 12 weeks for both groups. The training program occurred in the morning for 60 minutes, 3 times a week for 12 weeks. Statistical analysis included Wilcoxon's rank sum test, Mann-Whitney U test, chi-square test, and Fisher's exact test. P values <0.05 were considered to be statistically significant.

RESULTS

The 2 groups were homogeneous and comparable at baseline. The training group showed a significant improvement of aerobic capacity measured by anaerobic threshold VO(2) (14.67 +/- 3.03 versus 17.08 +/- 3.35 ml/kg/minute, P < 0.001). Comparison of the training group and control group after 12 weeks showed a significant difference relating to VO(2max) (24.31 +/- 4.61 versus 21.21 +/- 3.88 ml/kg/minute, P = 0.01) and anaerobic threshold VO(2) (17.08 +/- 3.35 versus 13.66 +/- 2.82 ml/kg/minute, P < 0.0001). After cardiovascular training, we found a significant improvement of Beck inventory score (8.37 +/- 12.79 versus 2.90 +/- 3.00, P < 0.001) and HAQ score (0.14 +/- 0.21 versus 0.06 +/- 0.19, P < 0.01) in the training group.

CONCLUSION

This study showed significant improvement in exercise tolerance, aerobic capacity, quality of life, and depression after a supervised cardiovascular training program in patients with SLE.

摘要

目的

确定有监督的心血管训练是否能改善系统性红斑狼疮（SLE）患者的运动耐量、有氧能力、抑郁状况、功能能力和生活质量。

方法

使用简短健康调查问卷（Short Form 36）、疼痛视觉模拟量表、疲劳量表、贝克抑郁量表和健康评估问卷（HAQ）对60名年龄在18至55岁之间的SLE女性患者进行评估，并让她们参与一项在跑步机上进行递增负荷并伴有计算机气体代谢分析的训练方案。使用SensorMedics Vmax29C分析仪（Sensor Medics，加利福尼亚州约巴林达）计算最大耗氧量（VO₂max）和无氧阈VO₂，并通过心电图测量心率。患者被分为两组：参与有监督心血管训练计划的训练组（41名患者）和未参与该计划的对照组（19名患者）。对两组患者在基线时和12周后对所有变量进行分析。训练计划在上午进行，每次60分钟，每周3次，共12周。统计分析包括威尔科克森秩和检验、曼 - 惠特尼U检验、卡方检验和费舍尔精确检验。P值<0.05被认为具有统计学意义。

结果

两组在基线时具有同质性且具有可比性。训练组通过无氧阈VO₂测量的有氧能力有显著改善（14.67±3.03对17.08±3.35毫升/千克/分钟，P<0.001）。12周后训练组与对照组的比较显示，在VO₂max（24.31±4.61对21.21±3.88毫升/千克/分钟，P = 0.01）和无氧阈VO₂（17.08±3.35对13.66±2.82毫升/千克/分钟，P<0.0001）方面存在显著差异。心血管训练后，我们发现训练组的贝克量表评分（8.37±12.79对2.90±3.00，P<0.001）和HAQ评分（0.14±0.21对0.06±0.19，P<0.01）有显著改善。