Jorgenson Eric, Liu Xin, Witte John S
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California 94143, USA.
Genet Epidemiol. 2005;29 Suppl 1:S86-90. doi: 10.1002/gepi.20114.
The case-control analyses group focused on a diverse set of questions, including study design, power, and analysis of case-control studies. Papers on study design examined various case-selection strategies, as well as ways to combine information from family- and population-based case-control data. The power of various approaches to case-control analyses was compared in several papers, while two papers chose to apply specific methods to analyzing the data. Two groups examined haplotype-related issues, including resolving un-phased haplotypes and comparing haplotype- and single-nucleotide polymorphism-based methods for analyzing data. Finally, one group examined the optimal number of markers for the genomic control approach to population stratification.
病例对照分析小组关注一系列不同的问题,包括研究设计、效能以及病例对照研究的分析。关于研究设计的论文探讨了各种病例选择策略,以及整合基于家庭和人群的病例对照数据信息的方法。几篇论文比较了病例对照分析的各种方法的效能,而有两篇论文选择应用特定方法来分析数据。两个小组研究了与单倍型相关的问题,包括解析未分型的单倍型以及比较基于单倍型和单核苷酸多态性的数据分析方法。最后,一个小组研究了用于群体分层的基因组对照方法的最佳标记数量。