Schook Lawrence, Beattie Craig, Beever Jonathan, Donovan Sharon, Jamison Russell, Zuckermann Federico, Niemi Steven, Rothschild Max, Rutherford Mark, Smith Douglas
University of Illinois, Institute for Genomic Biology, 382 ERML, 1201 W. Gregory Avenue, Urbana, IL 61801, USA.
Anim Biotechnol. 2005;16(2):183-90. doi: 10.1080/10495390500265034.
The opportunities for utilizing swine biomedical models are immense, particularly in models that address lifestyle issues (nutrition, stress, alcohol, drugs of abuse, etc.). However, in order to fully capitalize upon the promise, there needs to be a more general recognition of these cofactors, such as nutrition, as key modulators of phenotype via genomic, epigenetic, and postgenomic mechanisms. Furthermore, increased interactions between nutrition scientists and clinical and fundamental researchers in other disciplines, including developmental biology, immunology, neuroscience, oncology, and cardiovascular and gastrointestinal physiology, are required. Closing discussions focused on the need for future conferences at more frequent intervals to support interactions between the various disciplines. This was especially critical because of the global distribution of investigators.
利用猪生物医学模型的机会非常巨大，特别是在解决生活方式问题（营养、压力、酒精、滥用药物等）的模型中。然而，为了充分利用这一前景，需要更普遍地认识到这些辅助因素，如营养，作为通过基因组、表观遗传和后基因组机制调节表型的关键因素。此外，营养科学家与其他学科（包括发育生物学、免疫学、神经科学、肿瘤学以及心血管和胃肠生理学）的临床和基础研究人员之间需要加强互动。闭幕讨论集中在需要更频繁地召开未来会议以支持各学科之间的互动。由于研究人员分布在全球各地，这一点尤为关键。
