猪作为人类生物医学模型的重要性。

Importance of the pig as a human biomedical model.

机构信息

Animal Parasitic Diseases Laboratory, BARC, NEA, ARS, USDA, Beltsville, MD 20705, USA.

College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China.

出版信息

Sci Transl Med. 2021 Nov 24;13(621):eabd5758. doi: 10.1126/scitranslmed.abd5758.

DOI:10.1126/scitranslmed.abd5758

PMID:34818055

Abstract

Pigs have substantial potential as biomedical models for studying human developmental processes, congenital diseases, and pathogen response mechanisms in addition to utility as xenotransplant organ donors and tools for vaccine and drug design. The similarity of pigs to humans in anatomical size and structure, physiology, immunology, and genome enhances their potential as models for humans. Hence, it is imperative that research is relevant and reproducible in animal models that more closely resemble humans, such as the pig. This review summarizes the current status of pigs as an investigative model for humans and highlights their future applications.

摘要

猪除了可用作异种移植器官供体和疫苗及药物设计的工具外，还具有作为研究人类发育过程、先天性疾病和病原体反应机制的生物医学模型的巨大潜力。猪在解剖大小和结构、生理学、免疫学和基因组方面与人类的相似性增强了它们作为人类模型的潜力。因此，至关重要的是，研究在更接近人类的动物模型（如猪）中具有相关性和可重复性。本文综述了猪作为人类研究模型的现状，并强调了它们未来的应用。