Hicsonmez Ayse, Andrieu Meltem N, Karaca Metehan, Kurtman Cengiz
Department of Radiation Oncology, Anakra University School of Medicine, Turkey.
J Otolaryngol. 2005 Dec;34(6):379-83. doi: 10.2310/7070.2005.34604.
Most authors recommend aggressive management for sinonasal carcinoma treatment. In an attempt to determine the optimal treatment, we assessed the treatment results of our patients with nasal cavity and paranasal sinus carcinoma.
From January 1980 to December 2001, 40 patients with malignant tumours of the nasal cavity and the paranasal sinuses were treated. The median follow-up was 6 years. Thirty-two patients had tumours originating from the maxillary sinus. Thirteen patients had T1-T2 (32.5%) tumours and 27 patients had T3-T4 (67.5%) tumours. The treatment method was surgery plus radiotherapy in 24 patients (60%) and radiotherapy alone in 16 patients (40%).
The 5-year overall survival rate was 61%, whereas it was 65% for T1-T2 disease and 56% for T3-T4 disease. The 5-year local control rate was 58%, whereas it was 75% and 50% (p = .219) for T1-T2 and T3-T4 disease, respectively. In multivariate analysis; localization (p = .016), adjuvant radiotherapy (p = .040), local control (p = .05), and gender (p = .013 for female) were statistically significant factors.
The prognosis for patients with tumours of the sinonasal area is dependent on localization, tumour stage, and treatment modality. Because the most common site of treatment failure is the primary site, efforts to maximize local control should be undertaken.
大多数作者推荐对鼻窦癌采取积极的治疗方法。为了确定最佳治疗方案，我们评估了鼻腔和鼻窦癌患者的治疗结果。
1980年1月至2001年12月，对40例鼻腔和鼻窦恶性肿瘤患者进行了治疗。中位随访时间为6年。32例患者的肿瘤起源于上颌窦。13例患者为T1-T2期（32.5%）肿瘤，27例患者为T3-T4期（67.5%）肿瘤。治疗方法为24例患者（60%）采用手术加放疗，16例患者（40%）单纯放疗。
5年总生存率为61%，T1-T2期疾病为65%，T3-T4期疾病为56%。5年局部控制率为58%，T1-T2期和T3-T4期疾病分别为75%和50%（p = 0.219）。多因素分析显示，肿瘤部位（p = 0.016）、辅助放疗（p = 0.040）、局部控制情况（p = 0.05）和性别（女性p = 0.013）是具有统计学意义的因素。
鼻窦区域肿瘤患者的预后取决于肿瘤部位、肿瘤分期和治疗方式。由于最常见的治疗失败部位是原发部位，应努力最大限度地实现局部控制。
