Lavergne Anne, de Thoisy Benoît, Lacoste Vincent, Pascalis Hervé, Pouliquen Jean-François, Mercier Véronique, Tolou Hugues, Dussart Philippe, Morvan Jacques, Talarmin Antoine, Kazanji Mirdad
Laboratoire de Rétrovirologie, Institut Pasteur de la Guyane, 23 avenue Pasteur, BP6010, 97306 Cayenne cedex, French Guiana.
Virus Res. 2006 May;117(2):283-90. doi: 10.1016/j.virusres.2005.11.006. Epub 2005 Dec 15.
Mayaro (MAY) virus is a member of the genus Alphavirus in the family Togaviridae. Alphaviruses are distributed throughout the world and cause a wide range of diseases in humans and animals. Here, we determined the complete nucleotide sequence of MAY from a viral strain isolated from a French Guianese patient. The deduced MAY genome was 11,429 nucleotides in length, excluding the 5' cap nucleotide and 3' poly(A) tail. Nucleotide and amino acid homologies, as well as phylogenetic analyses of the obtained sequence confirmed that MAY is not a recombinant virus and belongs to the Semliki Forest complex according to the antigenic complex classification. Furthermore, analyses based on the E1 region revealed that MAY is closely related to Una virus, the only other South American virus clustering with the Old World viruses. On the basis of our results and of the alphaviruses diversity and pathogenicity, we suggest that alphaviruses may have an Old World origin.
马亚罗（MAY）病毒是披膜病毒科甲病毒属的成员。甲病毒分布于世界各地，可在人类和动物中引发多种疾病。在此，我们测定了从一名法属圭亚那患者分离出的病毒株的马亚罗病毒完整核苷酸序列。推导得出的马亚罗病毒基因组长度为11429个核苷酸，不包括5' 帽核苷酸和3' 聚腺苷酸尾。核苷酸和氨基酸同源性以及对所得序列的系统发育分析证实，马亚罗病毒不是重组病毒，根据抗原复合物分类，它属于塞姆利基森林病毒复合群。此外，基于E1区域的分析表明，马亚罗病毒与乌纳病毒密切相关，乌纳病毒是唯一一种与旧大陆病毒聚集在一起的南美病毒。根据我们的研究结果以及甲病毒的多样性和致病性，我们认为甲病毒可能起源于旧大陆。
