Scheel P J, Whelton A, Rossiter K, Watson A
Division of Nephrology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205.
J Clin Pharmacol. 1992 Jun;32(6):536-8. doi: 10.1177/009127009203200608.
Cholestyramine is a nonabsorbable anion exchange resin that is used predominantly for the treatment of hypercholesterolemia in adults and the management of acute diarrhea in children. The authors report two cases of severe hyperchloremic nonanion gap metabolic acidosis associated with the use of cholestyramine therapy. The authors recommend that patients taking cholestyramine who have concomitant renal insufficiency or who are volume depleted or who are taking spironolactone be monitored carefully for the emergence of a hyperchloremic metabolic acidosis.
消胆胺是一种不可吸收的阴离子交换树脂，主要用于治疗成人高胆固醇血症和小儿急性腹泻。作者报告了两例与消胆胺治疗相关的严重高氯性非阴离子间隙代谢性酸中毒病例。作者建议，对于正在服用消胆胺且伴有肾功能不全、容量不足或正在服用螺内酯的患者，应密切监测是否出现高氯性代谢性酸中毒。
