药物性代谢性酸中毒
Drug-Induced Metabolic Acidosis.
作者信息
Pham Amy Quynh Trang, Xu Li Hao Richie, Moe Orson W
机构信息
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390-8885, USA; Departments of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390-8885, USA; Baylor Family Medicine Residency at Garland, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390-8885, USA.
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390-8885, USA.
出版信息
F1000Res. 2015 Dec 16;4. doi: 10.12688/f1000research.7006.1. eCollection 2015.
Metabolic acidosis could emerge from diseases disrupting acid-base equilibrium or from drugs that induce similar derangements. Occurrences are usually accompanied by comorbid conditions of drug-induced metabolic acidosis, and clinical outcomes may range from mild to fatal. It is imperative that clinicians not only are fully aware of the list of drugs that may lead to metabolic acidosis but also understand the underlying pathogenic mechanisms. In this review, we categorized drug-induced metabolic acidosis in terms of pathophysiological mechanisms, as well as individual drugs' characteristics.
代谢性酸中毒可能源于破坏酸碱平衡的疾病，或源于诱发类似紊乱的药物。其发生通常伴有药物性代谢性酸中毒的合并症，临床结果可能从轻度到致命。临床医生不仅必须充分了解可能导致代谢性酸中毒的药物清单，还需要了解其潜在的致病机制。在本综述中，我们根据病理生理机制以及个别药物的特点，对药物性代谢性酸中毒进行了分类。
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