Institut für Mikrobiologie und Weinforschung, Johannes Gutenberg-Universität Mainz, Postfach 3980, D-6500 Mainz, and Abteilungen Pharmakologie und Chemotherapie, Hoechst AG, Postfach 80 03 20, D-6230 Frankfurt 80, Federal Republic of Germany.
Appl Environ Microbiol. 1988 Apr;54(4):1068-9. doi: 10.1128/aem.54.4.1068-1069.1988.
The Saccharomyces cerevisiae killer toxin KT 28, which inhibits sensitive yeasts, was shown to have no effect on several pathogenic fungi or on the protozoan Trichomonas vaginalis. At concentrations of about 0.1 mg/ml, a partial inhibition of the skin pathogenic fungi Trichophyton rubrum and Microsporum canis was observed at pH 6.5. No pharmacological activity was detected in various tests with several animal organs.
酿酒酵母杀伤毒素 KT28 可抑制敏感酵母,但对几种致病性真菌或原生动物阴道毛滴虫无作用。在 pH 值为 6.5 时,观察到该毒素在约 0.1mg/ml 的浓度下对皮肤病原菌红色毛癣菌和须毛癣菌有部分抑制作用。在对几种动物器官的多项药理试验中,未检测到该毒素的任何药理活性。