Mileo A M, Fanuele M, Battaglia F, Scambia G, Benedetti-Panici C, Mattei E, Mancuso S, Delpino A
Regina Elena Institute for Cancer Research, Roma, Italy.
Int J Biol Markers. 1992 Apr-Jun;7(2):114-8. doi: 10.1177/172460089200700208.
The HER-2/neu oncogene (a member of the Erb-like oncogene family) is distinct from but closely related to the c-erb B gene which encodes the epidermal growth factor receptor (EGFr). HER-2/neu gene amplification was found in a large number of mammary carcinomas and there was a strong correlation between this phenomenon and poor prognosis. In our study HER-2/neu oncogene expression was determined in 16 malignant ovarian tumors, 2 ovarian lymphomas and 5 normal ovaries. The HER-2/neu gene was found both in normal ovaries and malignant tumors, without any apparent difference among the various histological types. In all the specimens examined, HER-2/neu expression did not seem to be related to EGF binding capacity.
HER-2/neu癌基因（类表皮生长因子受体癌基因家族的成员）与编码表皮生长因子受体（EGFr）的c-erb B基因不同，但关系密切。在大量乳腺癌中发现了HER-2/neu基因扩增，且这一现象与预后不良密切相关。在我们的研究中，测定了16例恶性卵巢肿瘤、2例卵巢淋巴瘤和5例正常卵巢组织中HER-2/neu癌基因的表达。在正常卵巢组织和恶性肿瘤组织中均发现了HER-2/neu基因，不同组织学类型之间无明显差异。在所有检测标本中，HER-2/neu的表达似乎与表皮生长因子（EGF）结合能力无关。
