Vascular dementia: neuropathologic alterations and metabolic brain changes.

After reviewing the concepts of dementia, in general, and vascular dementia, in particular, this review discusses potential future approaches that may contribute to an improved definition of the clinical syndrome and the neuropathological features of vascular dementia. Specific brain alterations in high-energy phosphate compounds, as measured by nuclear magnetic resonance, may contribute to the separation between dementias with neurodegenerative diseases and those with ischemic (vascular or hemodynamic) disorders.