Supprian T, Kessler H, Retz W, Rösler M, Grunwald I, Reith W, Falkai P
Arbeitsgruppe Gerontopsychiatrie, Universitäts-Nervenklinik Homburg (Saar).
Radiologe. 2003 Jul;43(7):543-51. doi: 10.1007/s00117-003-0916-5. Epub 2003 Jun 24.
Due to a significant overlap of the two syndromes, differentiation of degenerative dementia of the Alzheimer-type from vascular dementia may be difficult even when imaging studies are available. White matter changes occur in many patients suffering from Alzheimer's disease. Little is known about the impact of white matter changes on the course and clinical presentation of Alzheimer's disease. High sensitivity of MRI in the detection of white matter alterations may account for over-diagnosing vascular dementia. The clinical significance of white matter alterations in dementia is still a matter of debate. The article reviews current concepts about the role of white matter alterations in dementia.
由于这两种综合征有显著重叠，即使有影像学研究，区分阿尔茨海默型退行性痴呆和血管性痴呆也可能很困难。许多阿尔茨海默病患者会出现白质改变。关于白质改变对阿尔茨海默病病程和临床表现的影响，目前知之甚少。MRI在检测白质改变方面的高灵敏度可能导致血管性痴呆的过度诊断。痴呆中白质改变的临床意义仍存在争议。本文综述了关于白质改变在痴呆中作用的当前概念。
