5-羟基喹啉-2-羧酸，是细菌氧化 5-氨基-2-萘磺酸的终产物。
5-hydroxyquinoline-2-carboxylic Acid, a dead-end metabolite from the bacterial oxidation of 5-aminonaphthalene-2-sulfonic Acid.
机构信息
Technische Chemie und Chemische Verfahrenstechnik, Universität-GH Paderborn, 4790 Paderborn, Institut für Organische Chemie, Universität Göttingen, 34 Göttingen, and Institut für Mikrobiologie der Universität Stuttgart, Azenbergstrasse 18, 7 Stuttgart 1, Germany.
出版信息
Appl Environ Microbiol. 1993 Jun;59(6):1898-903. doi: 10.1128/aem.59.6.1898-1903.1993.
Abstract
5-Aminonaphthalene-2-sulfonate (5A2NS) is converted by strain BN6 into 5-hydroxyquinoline-2-carboxylate (5H2QC). The authenticity of this new compound is confirmed by nuclear magnetic resonance and mass spectrometry. Its formation is explained by a spontaneous cyclization of the hypothetical metabolite 6'-amino-2'-hydroxybenzalpyruvate. The formation of 5H2QC as a dead-end product of 5A2NS prevents NADH regeneration so that 5A2NS oxidation is limited by the internal NADH pool.
摘要
5-氨基萘-2-磺酸（5A2NS）被 BN6 菌株转化为 5-羟基喹啉-2-羧酸（5H2QC）。通过核磁共振和质谱证实了这种新化合物的真实性。它的形成可以通过假设的代谢产物 6'-氨基-2'-羟基苯甲丙酮酸的自发环化来解释。5H2QC 的形成是 5A2NS 的末端产物，阻止了 NADH 的再生，因此 5A2NS 的氧化受到内部 NADH 池的限制。
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