Posner B I, Kelly P A, Friesen H G
Science. 1975 Apr 4;188(4183):57-9. doi: 10.1126/science.163493.
A prolactin receptor, present in adult female rat liver, can be induced in males by estrogen. Hypophysectomy diminished receptor levels in the female and rendered males unresponsive to estrogen. A renal pituitary implant blunted the decrease in hypophysectomized females and induced the receptor in hyophysectomized males. The increased receptor level in hypophysectomized males with a renal pituitary implant was preceded by a sustained elevation of circulating prolactin. Our observations suggest that prolactin induces its own receptor.
成年雌性大鼠肝脏中存在的催乳素受体可被雌激素诱导产生于雄性大鼠体内。垂体切除可降低雌性大鼠体内的受体水平，并使雄性大鼠对雌激素无反应。肾垂体植入可减弱垂体切除雌性大鼠受体水平的降低，并在垂体切除雄性大鼠中诱导受体产生。在肾垂体植入的垂体切除雄性大鼠中，受体水平升高之前循环催乳素持续升高。我们的观察结果表明，催乳素可诱导其自身受体的产生。
