一株链球菌在分批培养中产生透明质酸。
Production of hyaluronic Acid by a streptococcal strain in batch culture.
作者信息
Holmström B, Ricica J
机构信息
Department of Bacteriology, Karolinska Institutet, Stockholm, Sweden.
出版信息
Appl Microbiol. 1967 Nov;15(6):1409-13. doi: 10.1128/am.15.6.1409-1413.1967.
Abstract
A simple method for the production and preparation of hyaluronic acid (HA) is described. Three media were tested, which all supported relatively good yields of cells, but only in one of them were appreciable amounts of HA formed. In this medium, HA was produced during the logarithmic growth phase and showed a molecular weight of 7.3 x 10. HA prepared from 24-hr cultures of the same organism had a molecular weight of only 2.6 x 10. The kinetics of HA production in batch culture were studied, as well as of cell production and glucose consumption.
摘要
本文描述了一种生产和制备透明质酸（HA）的简单方法。测试了三种培养基，它们都能支持细胞获得相对较高的产量，但只有其中一种培养基能形成可观量的HA。在这种培养基中，HA在对数生长期产生，分子量为7.3×10。从同一生物体的24小时培养物中制备的HA分子量仅为2.6×10。研究了分批培养中HA的生产动力学，以及细胞生产和葡萄糖消耗的动力学。
相似文献
1
Production of hyaluronic Acid by a streptococcal strain in batch culture.一株链球菌在分批培养中产生透明质酸。
Appl Microbiol. 1967 Nov;15(6):1409-13. doi: 10.1128/am.15.6.1409-1413.1967.
2
Enhancement of acetyl-CoA by acetate co-utilization in recombinant Lactococcus lactis cultures enables the production of high molecular weight hyaluronic acid.在重组乳球菌培养物中通过共利用乙酸盐来增强乙酰辅酶 A 可实现高分子量透明质酸的生产。
Appl Microbiol Biotechnol. 2019 Sep;103(17):6989-7001. doi: 10.1007/s00253-019-09987-6. Epub 2019 Jul 2.
3
Hyaluronic acid production with Corynebacterium glutamicum: effect of media composition on yield and molecular weight.利用谷氨酸棒状杆菌生产透明质酸：培养基组成对产量和分子量的影响。
J Appl Microbiol. 2014 Sep;117(3):663-78. doi: 10.1111/jam.12553. Epub 2014 Jun 20.
4
Production of controlled molecular weight hyaluronic acid by glucostat strategy using recombinant Lactococcus lactis cultures.利用重组乳球菌培养物的葡萄糖调控策略生产可控分子量透明质酸。
Appl Microbiol Biotechnol. 2019 Jun;103(11):4363-4375. doi: 10.1007/s00253-019-09769-0. Epub 2019 Apr 9.
5
Culture Conditions Affect the Molecular Weight Properties of Hyaluronic Acid Produced by Streptococcus zooepidemicus.培养条件对兽疫链球菌产生的透明质酸的分子量特性有影响。
Appl Environ Microbiol. 1997 Jul;63(7):2759-64. doi: 10.1128/aem.63.7.2759-2764.1997.
6
Application of hydrocarbon and perfluorocarbon oxygen vectors to enhance heterologous production of hyaluronic acid in engineered Bacillus subtilis.烃类和全氟碳类氧载体在工程枯草芽孢杆菌中增强透明质酸异源生产中的应用。
Biotechnol Bioeng. 2018 May;115(5):1239-1252. doi: 10.1002/bit.26551. Epub 2018 Feb 26.
7
Highly efficient production of hyaluronic acid by Streptococcus zooepidemicus R42 derived from heterologous expression of bacterial haemoglobin and mutant selection.通过猪源链球菌R42异源表达细菌血红蛋白及突变体筛选高效生产透明质酸
Lett Appl Microbiol. 2016 Apr;62(4):316-22. doi: 10.1111/lam.12546.
8
Enhanced hyaluronic acid production by a two-stage culture strategy based on the modeling of batch and fed-batch cultivation of Streptococcus zooepidemicus.基于兽疫链球菌分批和补料分批培养模型的两阶段培养策略提高透明质酸产量
Bioresour Technol. 2008 Nov;99(17):8532-6. doi: 10.1016/j.biortech.2008.02.035. Epub 2008 Apr 7.
9
Influence of hyaluronidase addition on the production of hyaluronic acid by batch culture of Streptococcuszooepidemicus.添加透明质酸酶对兽疫链球菌分批培养生产透明质酸的影响。
Food Chem. 2008 Oct 15;110(4):923-6. doi: 10.1016/j.foodchem.2008.02.082. Epub 2008 Mar 4.
10
Microbial production of hyaluronic acid from agricultural resource derivatives.微生物利用农业资源衍生物生产透明质酸。
Bioresour Technol. 2010 Aug;101(16):6506-9. doi: 10.1016/j.biortech.2010.03.074. Epub 2010 Apr 3.
引用本文的文献
1
Characterization of the Molecular Weight of Hyaluronan in Eye Products Using a Novel Method of Size Exclusion High-Pressure Liquid Chromatography.采用新型体积排阻高效液相色谱法对眼部产品中透明质酸分子量进行表征。
Transl Vis Sci Technol. 2023 Apr 3;12(4):13. doi: 10.1167/tvst.12.4.13.
2
Comparative Analysis of Hyaluronidase-Mediated Degradation Among Seven Hyaluronic Acid Fillers in Hairless Mice.无毛小鼠中七种透明质酸填充剂的透明质酸酶介导降解的比较分析
Clin Cosmet Investig Dermatol. 2021 Mar 8;14:241-248. doi: 10.2147/CCID.S300960. eCollection 2021.
3
Enhanced hyluronic acid production in by over expressing HasA and molecular weight control with Niscin and glucose.通过过表达HasA增强透明质酸的产生以及用乳链菌肽和葡萄糖控制分子量。
Biotechnol Rep (Amst). 2017 Mar 2;16:65-70. doi: 10.1016/j.btre.2017.02.007. eCollection 2017 Dec.
4
Isolation of streptococcal hyaluronate synthase.链球菌透明质酸合酶的分离
Biochem J. 1986 May 1;235(3):887-9. doi: 10.1042/bj2350887.
5
Hyaluronic acid capsule: strategy for oxygen resistance in group A streptococci.透明质酸荚膜：A 组链球菌的抗氧策略。
J Bacteriol. 1979 Dec;140(3):1090-7. doi: 10.1128/jb.140.3.1090-1097.1979.
本文引用的文献
1
HOST-PARASITE RELATIONSHIPS AMONG GROUP A STREPTOCOCCI. I. HYALURONIC ACID PRODUCTION BY VIRULENT AND AVIRULENT STRAINS.A组链球菌的宿主-寄生虫关系。I. 有毒力和无毒力菌株的透明质酸产生
J Bacteriol. 1964 Jun;87(6):1452-6. doi: 10.1128/jb.87.6.1452-1456.1964.
2
ISOLATION OF HYALURONIC ACID FROM BROTH CULTURES OF STREPTOCOCCI.从链球菌肉汤培养物中分离透明质酸
J Biol Chem. 1964 Mar;239:726-8.
3
Isolation and purification of streptococcal hyaluronic acid.链球菌透明质酸的分离与纯化
Proc Soc Exp Biol Med. 1959 Oct;102:125-7. doi: 10.3181/00379727-102-25165.
4
Fractionation of hyaluronic acid. The polydispersity of hyaluronic acid from the bovine vitreous body.透明质酸的分级分离。来自牛玻璃体的透明质酸的多分散性。
Biochim Biophys Acta. 1960 Aug 26;42:476-85. doi: 10.1016/0006-3002(60)90826-x.
5
The growth of micro-organisms in relation to their energy supply.微生物生长与其能量供应的关系。
J Gen Microbiol. 1960 Dec;23:457-69. doi: 10.1099/00221287-23-3-457.
6
Rapid specific method for determination of aldosaccharides in body fluids.体液中醛糖测定的快速特异性方法。
Nature. 1959 Jan 10;183(4654):108-9. doi: 10.1038/183108a0.
7
The purification of hyaluronic acid by the use of charcoal.
Biochim Biophys Acta. 1957 May;24(2):397-400. doi: 10.1016/0006-3002(57)90211-1.
8
9
The biosynthesis of hyaluronic acid by group A Streptococcus. I. Utilization of 1-C14-glucose.A 组链球菌合成透明质酸。I. 1-C14-葡萄糖的利用
J Biol Chem. 1953 Jul;203(1):213-25.
Zotero 插件