Tetsuo I, Tomiyama S
Department of Otorhinolaryngology, Nippon Medical School, Tokyo.
Nihon Jibiinkoka Gakkai Kaiho. 1992 Jun;95(6):809-16. doi: 10.3950/jibiinkoka.95.809.
Following direct challenge with KLH antigen primary or secondary (after systemic immunization) to the ES (endolymphatic sac) in guinea pigs, ECoG (electrocochleograms) were recorded from the round window induced by click and tone pips. The recordings were carried out on the 2nd, 7th and 21st days after local antigen challenge. There were no abnormal findings in the ECoG of the primary antigen challenged animals. On the other hand, prolongation of latencies, decrease in amplitudes of APs (compound action potentials) and increases in SP/AP ratios were observed in the 2nd day recordings of the secondary antigen challenged animals. However, all parameters of ECoG in the 7th day recordings were normal. Decreases in AP amplitudes were again found in the 21st day recordings. The ECoG findings with click and tone pip stimulation showed similar results. From these findings, in conjunction with morphological observations, it is speculated that these ECoG findings are caused by immuno-injury to the ES and cochlea, as well as the resultant endolymphatic hydrops which develops acutely and gradually subsides after secondary challenge.
在用KLH抗原对豚鼠的内淋巴囊进行初次或二次（全身免疫后）直接攻击后，通过短声和短纯音诱发，从圆窗记录耳蜗电图（ECoG）。记录在局部抗原攻击后的第2天、第7天和第21天进行。初次抗原攻击动物的耳蜗电图未发现异常。另一方面，在二次抗原攻击动物的第2天记录中，观察到潜伏期延长、复合动作电位（AP）幅度降低以及SP/AP比值增加。然而，第7天记录的所有耳蜗电图参数均正常。在第21天的记录中再次发现AP幅度降低。短声和短纯音刺激的耳蜗电图结果相似。从这些发现以及形态学观察推测，这些耳蜗电图发现是由对内淋巴囊和耳蜗的免疫损伤以及继发攻击后急性发生并逐渐消退的内淋巴积水所致。
