Galiana Gigi, Branca Rosa T, Warren Warren S
Princeton University, Department of Chemistry, Princeton, New Jersey, USA.
J Am Chem Soc. 2005 Dec 21;127(50):17574-5. doi: 10.1021/ja054463m.
Clinical magnetic resonance spectroscopy is typically limited by magnetic inhomogeneities which destroy spectral resolution, but intermolecular zero quantum coherences (iZQCs) are insensitive to such inhomogeneities. iZQC resolution in vivo, however, has been hampered by physiological fluctuations over the time scale of the two-dimensional acquisition. A faster iZQC sequence will allow us to average away these fluctuations, and thus we present a new approach to ultrafast two-dimensional spectroscopy. This communication reports iZQC experiments acquiring up to 31 t1-points per scan, as well as extensions to a broad range of other 2D sequences.
临床磁共振波谱通常受限于破坏谱分辨率的磁场不均匀性，但分子间零量子相干（iZQC）对这种不均匀性不敏感。然而，在二维采集的时间尺度上，体内iZQC分辨率一直受到生理波动的阻碍。更快的iZQC序列将使我们能够消除这些波动的影响，因此我们提出了一种用于超快二维波谱的新方法。本通讯报道了每次扫描可采集多达31个t1点的iZQC实验，以及对广泛的其他二维序列的扩展。
