Department of Chemistry, Duke University, Durham, North Carolina, USA.
Int J Hyperthermia. 2010;26(7):725-34. doi: 10.3109/02656736.2010.499527.
A review of MRI temperature imaging methods based on intermolecular multiple quantum coherences (iMQCs) is presented. Temperature imaging based on iMQCs can provide absolute temperature maps that circumvent the artefacts that other proton frequency shift techniques suffer from such as distortions to the detected temperature due to susceptibility changes and magnetic field inhomogeneities. Thermometry based on iMQCs is promising in high-fat tissues such as the breast, since it relies on the fat signal as an internal reference. This review covers the theoretical background of iMQCs, and the necessary adaptations for temperature imaging using iMQCs.
Data is presented from several papers on iMQC temperature imaging. These studies were done at 7T in both phantoms and in vivo. Results from phantoms of cream (homogeneous mixture of water and fat) are presented as well as in vivo temperature maps in obese mice.
Thermometry based on iMQCs offers the potential to provide temperature maps which are free of artefacts due to susceptibility and magnetic field inhomogeneities, and detect temperature on an absolute scale.
The data presented in the papers reviewed highlights the promise of iMQC-based temperature imaging in fatty tissues such as the breast. The change in susceptibility of fat with temperature makes standard proton frequency shift methods (even with fat suppression) challenging and iMQC-based imaging offers an alternative approach.
本文回顾了基于分子间多量子相干（iMQCs）的 MRI 温度成像方法。基于 iMQCs 的温度成像是一种绝对温度图，可以避免其他质子频率偏移技术所遭受的伪影，如由于磁化率变化和磁场不均匀性导致检测到的温度失真。基于 iMQCs 的测温在富含脂肪的组织（如乳房）中很有前途，因为它依赖于脂肪信号作为内部参考。本综述涵盖了 iMQCs 的理论背景，以及使用 iMQCs 进行温度成像的必要适应性。
本文呈现了几篇关于 iMQC 温度成像的论文中的数据。这些研究在 7T 下的体模和体内进行。本文呈现了乳霜（水和脂肪的均匀混合物）体模的结果，以及肥胖小鼠的体内温度图。
基于 iMQCs 的测温具有提供无磁化率和磁场不均匀性伪影的温度图的潜力，并能够以绝对标度检测温度。
综述中呈现的论文数据突显了基于 iMQCs 的温度成像在富含脂肪的组织（如乳房）中的应用前景。脂肪的磁化率随温度变化使得标准的质子频率偏移方法（即使采用脂肪抑制）具有挑战性，而基于 iMQCs 的成像提供了一种替代方法。
