Percec Virgil, Dulcey Andrés E, Peterca Mihai, Ilies Monica, Sienkowska Monika J, Heiney Paul A
Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
J Am Chem Soc. 2005 Dec 21;127(50):17902-9. doi: 10.1021/ja056313h.
The synthesis of dendritic dipeptides (4-3,4-3,5)12G2-CH2-X-L-Tyr-L-Ala-OMe with X = Boc, Moc, and Ac; their self-assembly in bulk and in solution; and the structural and retrostructural analysis of their supramolecular helical porous assemblies are reported. The dimensions, structure, internal order, thermal stability of the supramolecular helical pores, and conformations of the dendron and supramolecular dendrimer are programmed by the nature of the protective groups of the dipeptide. The ability of the protective groups to program the structure of the helical pore reveals the simplest design strategy that complements the more complex strategies based on the architecture of the dendron, the stereochemistry, and the structure of the dipeptide.
报道了树枝状二肽(4-3,4-3,5)12G2-CH2-X-L-Tyr-L-Ala-OMe（其中X = Boc、Moc和Ac）的合成；它们在本体和溶液中的自组装；以及对其超分子螺旋多孔组装体的结构和逆向结构分析。超分子螺旋孔的尺寸、结构、内部有序性、热稳定性以及树枝单元和超分子树枝状大分子的构象由二肽保护基团的性质来调控。保护基团调控螺旋孔结构的能力揭示了一种最简单的设计策略，它补充了基于树枝单元结构、立体化学和二肽结构的更复杂策略。
