Nakayama S, Matsushita A, Ichiba S, Yabe H, Nagai K
Department of Immunohematology, Kobe City General Hospital.
Rinsho Ketsueki. 1992 Feb;33(2):157-61.
The efficacy of traditional Chinese medicine (Kampo medicine) was examined in 40 patients with steroid-unresponsive idiopathic thrombocytopenic purpura (ITP). All patients were, at first, given Hochuekihi-to, and when they were refractory, therapy was switched to Sairei-to, Ninjinyoei-to, and Kamikihi-to. The efficacy rate was 20.0% by Hochuekihi-to, 20.7% by Sairei-to, 5.5% by Ninjinyoei-to and 6.7% by Kamikihi-to, respectively. Thus, overall responders were 12 in 40 patients with an effective rate of 30.0%. The mechanism of action of traditional Chinese medicine is discussed in relation to the production of various kinds of cytokines.
对40例激素无反应性特发性血小板减少性紫癜（ITP）患者的中药（汉方医学）疗效进行了研究。所有患者起初均给予补中益气汤，若出现难治性情况，则将治疗换为柴苓汤、人参养荣汤和加味归脾汤。补中益气汤的有效率为20.0%，柴苓汤为20.7%，人参养荣汤为5.5%，加味归脾汤为6.7%。因此，40例患者中有12例总体有效，有效率为30.0%。结合各种细胞因子的产生对中药的作用机制进行了讨论。
