Inoue Y, Nakagawa Y, Sawanobori M, Suzuki K, Enomoto H
Japanese Red Cross Medical Center, Department of Hematology.
Rinsho Ketsueki. 1998 Mar;39(3):193-7.
A 54-year-old woman, who had been given a diagnosis of idiopathic thrombocytopenic purpura (ITP) refractory to steroid therapy, was admitted to our hospital because of severe bleeding tendency. Splenectomy, high dose vitamin-C and interferon-alpha were not effective, although high-dose gamma-globulin had some effect. Since high-dose glucocorticoid was effective temporarily, we decided to perform chemotherapy. Seven courses of CVP chemotherapies (CVP; CPM 500 mg, VCR 2 mg, PSL 50 mg) prevented severe bleeding and did not have serious toxicity. Chemotherapy can be indicated for refractory ITP reactive to immunosuppressive therapy such as high-dose glucocorticoid.
一名54岁女性，此前被诊断为对类固醇治疗无效的特发性血小板减少性紫癜（ITP），因严重出血倾向入住我院。脾切除术、大剂量维生素C和干扰素-α均无效，尽管大剂量丙种球蛋白有一定效果。由于大剂量糖皮质激素有暂时疗效，我们决定进行化疗。七个疗程的CVP化疗（CVP；环磷酰胺500mg、长春新碱2mg、泼尼松龙50mg）预防了严重出血，且无严重毒性。对于对免疫抑制治疗（如大剂量糖皮质激素）有反应的难治性ITP，可考虑化疗。
