Kumagai S, Matsunaga I, Kusaka Y
Department of Occupational Health, Osaka Prefectural Institute of Public Health.
Sangyo Igaku. 1992 Jan;34(1):30-8. doi: 10.1539/joh1959.34.30.
Daily exposure averages (8-h TWAs) to hazardous substances may vary considerably day to day, even though a worker is engaged in the same job. Previously we proposed a method to evaluate a long-term exposure condition with interday fluctuation using some exposure measurements. As it is assumed that 8-h TWAs are log-normally distributed, geometric standard deviation (sigma g) representing true interday fluctuation of 8-h TWAs should be estimated. If a single day's 8-h TWA of a worker is measured, sigma g of his own distribution of 8-h TWAs cannot be estimated. Therefore, to evaluate a long-term condition using a single day's 8-h TWA, representative sigma g in all industrial workplaces must be determined beforehand. To investigate sigma g observed in many industrial workplaces, two days' 8-h TWAs of each worker were measured in a week on 260 workers exposed to 19 hazardous substances. Sg2 (geometric standard deviation estimated by two samples) ranged from 1.00 to 8.22 with a median of 1.47 and a 90% upper limit of 2.47. Transforming Sg2 into sigma g, median and 90% upper limit of sigma g were 1.75 and 2.47, respectively. According to a classification scheme in the proposed method, exposure levels (I to III) were calculated using sigma g of 1.75 and 2.47. A long-term exposure condition to hazardous substances can be evaluated by comparing a single day's 8-h TWA with the exposure levels.
即使工人从事相同工作,有害物质的每日暴露平均值(8小时时间加权平均值)也可能每天有很大差异。此前我们提出了一种方法,通过一些暴露测量来评估存在日间波动的长期暴露状况。由于假定8小时时间加权平均值呈对数正态分布,所以应估计代表8小时时间加权平均值真实日间波动的几何标准差(σg)。如果只测量一名工人某一天的8小时时间加权平均值,就无法估计其自身8小时时间加权平均值分布的σg。因此,为了使用某一天的8小时时间加权平均值来评估长期状况,必须事先确定所有工业工作场所的代表性σg。为了调查许多工业工作场所观察到的σg,对260名接触19种有害物质的工人,在一周内测量了他们每人两天的8小时时间加权平均值。Sg2(由两个样本估计的几何标准差)范围为1.00至8.22,中位数为1.47,90%上限为2.47。将Sg2转换为σg后,σg的中位数和90%上限分别为1.75和2.47。根据所提方法中的分类方案,使用1.75和2.47的σg计算暴露水平(I至III)。通过将某一天的8小时时间加权平均值与暴露水平进行比较,可以评估对有害物质的长期暴露状况。