Nagata Naoki, Nakayama Yoshifumi, Matsumoto Kentaro, Inoue Yuzuru, Shibao Kazunori, Higure Aiichiro, Hirata Keiji, Itoh Hideaki
Dept. of Surgery I, University of Occupational and Environmental Health, School of Medicine.
Gan To Kagaku Ryoho. 2005 Dec;32(13):2101-4.
The patient was a 40-year-old woman who had unresectable advanced gastric cancer with invasion of liver and dissemination to the peritoneal wall. Neoadjuvant chemotherapy consisting of paclitaxel (PTX) and CDDP was performed. PTX (80 mg/m2), and CDDP (25 mg/m2) was administered weekly on day 1, 8 and 15 as one cycle. After four cycles of PTX/CDDP administration,invasion of liver and gastric tumor had decreased to almost normal size, and total gastrectomy was performed. After operation, the patient was treated with six courses of PTX/CDDP and survived without recurrence as of this writing. PTX/CDDP was associated with few adverse events in hospital visits, and thought to be an effective chemotherapy against advanced gastric cancer.
该患者为一名40岁女性，患有无法切除的晚期胃癌，已侵犯肝脏并扩散至腹膜壁。进行了由紫杉醇（PTX）和顺铂（CDDP）组成的新辅助化疗。PTX（80mg/m²）和CDDP（25mg/m²）在第1、8和15天每周给药一次，作为一个周期。在给予四个周期的PTX/CDDP后，肝脏侵犯和胃肿瘤已缩小至几乎正常大小，并进行了全胃切除术。术后，患者接受了六个疗程的PTX/CDDP治疗，截至撰写本文时无复发存活。PTX/CDDP在住院期间不良反应较少，被认为是治疗晚期胃癌的有效化疗方法。
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