Statsenko M E, Rybak V A, Govorukha O A
Kardiologiia. 2005;45(12):48-52.
Aim of the study was clarification of the role of psychological characteristics of personality of patients, relationship between parameters of quality of life and clinical characteristics of the disease and their effect on peculiarities of the course of curative-rehabilitational process as well as clarification of spectrum of clinical activity and safety of tianeptine in anxiety-depressive states in patients with chronic heart failure in early post infarction period. Of 80 patients with anxiety-depressive disorders studied on days 15-30 after onset of disease, 30 received tianeptine (37.5 mg/day) for 3-6 months and 50 comprised control group. Significant reduction of symptoms of anxiety and depression and of cognitive-mnestic functions which occurred in tianeptine treated patients was accompanied with diminished severity of symptoms of heart failure and coronary insufficiency, lowering of index of local myocardial contractility and growth of ejection fraction. All of this resulted in improvement of quality of life of postinfarction patients, shortening of terms of rehabilitational period and allowed the patients to adapt better to surrounding reality.
本研究的目的是阐明患者人格心理特征的作用、生活质量参数与疾病临床特征之间的关系及其对康复治疗过程特点的影响，以及阐明噻奈普汀在心肌梗死后早期慢性心力衰竭患者焦虑抑郁状态下的临床活性谱和安全性。在发病后15 - 30天对80例焦虑抑郁障碍患者进行研究，其中30例接受噻奈普汀（37.5毫克/天）治疗3 - 6个月，50例作为对照组。接受噻奈普汀治疗的患者出现焦虑和抑郁症状以及认知记忆功能显著减轻，同时心力衰竭和冠状动脉供血不足症状的严重程度降低，局部心肌收缩力指标下降，射血分数增加。所有这些都导致心肌梗死后患者生活质量改善，康复期缩短，并使患者能更好地适应周围现实。
