Marey C, Ganry H, Delalleau B, Kamoun A
I.R.I.S., Courbevoie.
Presse Med. 1991 Nov 14;20(37):1828-36.
Tianeptine is a new tricyclic antidepressant. Double blind studies comparing tianeptine with imipramine and amitriptyline have shown the effectiveness of tianeptine's antidepressor action, its properties of non-specific symptoms related to behaviour disorders (anxiety, inhibition ...) and its action on somatic complaints expressed by depressed patients. Tianeptine is an effective antidepressant in cases of depression with anxiety or alcoholism and also leads to good therapeutic response in cases of dysthemia. In depressions with melancholy and endogenous criteria, the expected percentage of responding patients has been observed with tianeptine. A reinforcement of the therapeutic effect has been demonstrated after 6 months of treatment. Its excellent clinical and parclinical acceptability, especially in long term treatment of patients at risk such as elderly depressed patients or alcoholic patients, makes tianeptine a first intention antidepressant.
噻奈普汀是一种新型三环类抗抑郁药。将噻奈普汀与丙咪嗪和阿米替林进行比较的双盲研究表明，噻奈普汀具有抗抑郁作用，对与行为障碍相关的非特异性症状（焦虑、抑制……）有作用，且对抑郁症患者的躯体不适有疗效。噻奈普汀在伴有焦虑或酒精中毒的抑郁症病例中是一种有效的抗抑郁药，在心境恶劣病例中也能产生良好的治疗反应。在伴有忧郁和内源性标准的抑郁症中，使用噻奈普汀观察到了预期的有效患者百分比。治疗6个月后已证明治疗效果有所增强。其出色的临床和临床前可接受性，尤其是在对老年抑郁症患者或酒精中毒患者等高危患者的长期治疗中，使噻奈普汀成为首选的抗抑郁药。
