母血清筛查获得的风险评估对羊膜穿刺术发生率的影响。

The influence of risk estimates obtained from maternal serum screening on amniocentesis rates.

作者信息

Mueller V M, Huang T, Summers A M, Winsor S H M

机构信息

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.

出版信息

Prenat Diagn. 2005 Dec;25(13):1253-7. doi: 10.1002/pd.1321.

DOI:10.1002/pd.1321

PMID:16353274

Abstract

OBJECTIVE

To investigate the influence of Down syndrome risk estimates obtained from maternal serum screening (MSS) on women's choices regarding amniocentesis.

METHODS

Women who screened positive for Down syndrome by an Ontario MSS program between 1993 and 1998 were grouped on the basis of their risk estimate and ethnicity. Amniocentesis uptake rates between the groups were compared in order to determine how the MSS risk estimate influenced uptake.

RESULTS

Analysis of 16 792 women showed that amniocentesis uptake rates increased as the estimated risk increased. Uptake in women < or = 35 was higher than that for older women (70% vs 60%, p = 0.001). Uptake in Caucasian and Asian women was higher than the uptake in Black women (67% vs 49%, p = 0.001). Women aged 35 years or older were more likely to proceed with amniocentesis if the MSS risk estimate was higher than their age-specific risk.

CONCLUSION

The increase in amniocentesis rate paralleled the increase in MSS risk estimate for Down syndrome. Risk-specific amniocentesis rates are higher in women aged less than 35 years. Women aged 35 years or older whose risk estimate by MSS is lower than their age-specific risk are less likely to opt for amniocentesis.

摘要

目的

研究通过母血清筛查（MSS）获得的唐氏综合征风险评估对女性羊水穿刺选择的影响。

方法

1993年至1998年间在安大略省MSS项目中唐氏综合征筛查呈阳性的女性，根据其风险评估和种族进行分组。比较各组之间的羊水穿刺接受率，以确定MSS风险评估如何影响接受情况。

结果

对16792名女性的分析表明，羊水穿刺接受率随着估计风险的增加而上升。年龄≤35岁女性的接受率高于年龄较大女性（70%对60%，p = 0.001）。白种人和亚洲女性的接受率高于黑人女性（67%对49%，p = 0.001）。如果MSS风险评估高于其特定年龄风险，35岁及以上的女性更有可能进行羊水穿刺。