Ahn Joong Ho, Kim Mi Ra, Kim Ki Hyung
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Acta Otolaryngol. 2005 Nov;125(11):1176-9. doi: 10.1080/00016480510012327.
Prophylactic i.v. administration of 10 mg of dexamethasone reduced postoperative dizziness and nausea without adverse effects in patients undergoing canal wall-up mastoidectomy, but did not reduce postoperative pain.
To investigate the efficacy of dexamethasone in reducing postoperative dizziness, nausea and pain in patients undergoing canal wall-up mastoidectomy.
A prospective, randomized, double-blind study was performed between January 2002 and December 2004. A total of 162 patients (66 males, 96 females) scheduled for canal wall-up mastoidectomy were enrolled and randomly assigned to receive either i.v. dexamethasone (10 mg in 2 ml) or i.v. placebo (2 ml of normal saline) during mastoidectomy. A standard general anesthetic technique was employed throughout the surgical procedure. At 3, 6 and 24 h after surgery, patients completed questionnaires regarding postoperative dizziness, nausea and pain, with their responses being given on a visual analog scale.
There were no postoperative complications in either group. Compared to the placebo group, the dexamethasone group showed reduced postoperative dizziness and reduced nausea (p<0.05 for both) at 24 h postoperatively. Compared to the placebo group, dexamethasone had no effect on postoperative pain.
对于接受开放式乳突根治术的患者，静脉注射10毫克地塞米松进行预防性给药可减轻术后头晕和恶心，且无不良反应，但不能减轻术后疼痛。
探讨地塞米松对接受开放式乳突根治术患者术后头晕、恶心和疼痛的缓解效果。
2002年1月至2004年12月进行了一项前瞻性、随机、双盲研究。共有162例计划接受开放式乳突根治术的患者（66例男性，96例女性）入组，并随机分配在乳突切除术中接受静脉注射地塞米松（2毫升含10毫克）或静脉注射安慰剂（2毫升生理盐水）。整个手术过程采用标准的全身麻醉技术。术后3小时、6小时和24小时，患者完成关于术后头晕、恶心和疼痛的问卷调查，其回答采用视觉模拟评分法。
两组均无术后并发症。与安慰剂组相比，地塞米松组术后24小时的头晕和恶心症状减轻（两者p<0.05）。与安慰剂组相比，地塞米松对术后疼痛无影响。
