Esteller E, Modolell I, Segarra F, Matiño E, Enrique A, Ademà J M, Estivill E
Servicio de Otorrinolaringología, Hospital General de Catalunya, San Cugat del Vallès, Barcelona.
Acta Otorrinolaringol Esp. 2005 Nov;56(9):411-5. doi: 10.1016/s0001-6519(05)78639-8.
Patients with mild or moderate Sleep Apnea Syndrome (SAS) need wider therapeutic scope options according to their disease severity.
To consider including proton pump inhibitors (PPI) to the therapeutical alternatives of these patients.
A prospective study was designed, among patients with SAS. Nocturnal polysomnography and double channel pHmetry were performed simultaneously.
From the 18 patients included in this preliminary phase, in three (16.7%) nocturnal proximal ph monitoring was positive. These 3 patients were treated with PPI during at least 3 months with a very satisfactory outcome in two of them.
Treatment with PPI may be a useful therapeutical alternative in patients with mild to moderate SAS.
轻度或中度睡眠呼吸暂停综合征（SAS）患者根据其疾病严重程度需要更广泛的治疗选择。
考虑将质子泵抑制剂（PPI）纳入这些患者的治疗选择。
设计了一项针对SAS患者的前瞻性研究。同时进行夜间多导睡眠图和双通道pH监测。
在这个初步阶段纳入的18名患者中，3名（16.7%）夜间近端pH监测呈阳性。这3名患者接受了至少3个月的PPI治疗，其中2名效果非常令人满意。
PPI治疗可能是轻度至中度SAS患者的一种有用治疗选择。
