Fukuyama Takahide, Yamaura Ryo, Higashibeppu Yuki, Okamura Takahiro, Ryu Ilhyong, Kondo Teruyuki, Mitsudo Take-aki
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Org Lett. 2005 Dec 22;7(26):5781-3. doi: 10.1021/ol052291s.
[reaction: see text] Catalytic [2 + 2 + 1 + 1] cocyclization reaction of an alkyne, an alkene, and two molecules of carbon monoxide, leading to functionalized hydroquinones, was studied. Using [Cp*RuCl2]2 as a catalyst, we found that a variety of electron-deficient alkenes, such as alpha,beta-unsaturated ketones, esters, amides, and nitriles, can be employed as an alkene coupling partner to give the corresponding hydroquinones.
[反应：见正文] 研究了炔烃、烯烃与两分子一氧化碳的催化[2 + 2 + 1 + 1]共环化反应，该反应生成官能化对苯二酚。使用[Cp*RuCl₂]₂作为催化剂，我们发现多种缺电子烯烃，如α,β-不饱和酮、酯、酰胺和腈，可作为烯烃偶联伙伴以得到相应的对苯二酚。
