Mawhorter Steven D, Sierk Anne, Staugaitis Susan M, Avery Robin K, Sobecks Ronald, Prayson Richard A, Procop Gary W, Yen-Lieberman Belinda
Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Clin Lymphoma Myeloma. 2005 Nov;6(3):248-50. doi: 10.3816/CLM.2005.n.053.
West Nile virus (WNV) infections are potentially life threatening in immunocompromised hosts. Currently, the best diagnostic test is serology. Reverse-transcriptase polymerase chain reaction (RT-PCR) testing has a role, but, because WNV is a cell-associated neurotropic virus, RT-PCR results are frequently negative even in cases of active infection. We present a case in which serology results were persistently negative because the patient was immunocompromised following lymphoma treatment. The role of humoral immunity in resolution of WNV is also discussed.
西尼罗河病毒（WNV）感染对免疫功能低下的宿主有潜在生命威胁。目前，最佳诊断检测方法是血清学检测。逆转录聚合酶链反应（RT-PCR）检测也有一定作用，但由于WNV是一种与细胞相关的嗜神经病毒，即使在活动性感染病例中，RT-PCR结果也常常为阴性。我们报告一例血清学结果持续为阴性的病例，原因是患者在淋巴瘤治疗后免疫功能低下。本文还讨论了体液免疫在西尼罗河病毒感染消退中的作用。
