O'Rourke Robert W, Kay Thomas, Scholz Mark H, Diggs Brian, Jobe Blair A, Lewinsohn David M, Bakke Antony C
Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Obes Surg. 2005 Nov-Dec;15(10):1463-8. doi: 10.1381/096089205774859308.
Obesity affects the regulation of immune and inflammatory responses. This study characterizes differences in peripheral blood lymphocyte phenotype in obese humans.
Frequencies of lymphocyte subsets among peripheral blood mononuclear cells were compared between 10 obese (BMI > or = 35) and 10 lean subjects, as determined by antibodies directed against cluster differentiation (CD) markers.
Obese patients demonstrated an increased frequency of CD3+CD4+ T-cells (mean difference 12%, P=0.004), a decreased frequency of CD3+CD8+ T-cells (mean difference 9.4%, P=0.016) and an increased frequency of CD3+CD8+CD95+ T-cells (mean difference 13.3%, P=0.032). No other differences among T-cell or monocyte subsets were noted.
Obesity is associated with alterations in frequencies of peripheral CD4+ and CD8+ T-cells and aberrations in the expression of CD95 among CD8+ T-cells. These data suggest both CD4+ and CD8+ T-cell compartments, as well as the regulation of CD95 expression on CD8+ T-cells, as targets for further study into obesity's effects on the immune system.
肥胖会影响免疫和炎症反应的调节。本研究旨在描述肥胖人群外周血淋巴细胞表型的差异。
通过针对分化簇（CD）标志物的抗体，比较了10名肥胖者（BMI≥35）和10名瘦人外周血单个核细胞中淋巴细胞亚群的频率。
肥胖患者CD3+CD4+T细胞频率增加（平均差异12%，P = 0.004），CD3+CD8+T细胞频率降低（平均差异9.4%，P = 0.016），CD3+CD8+CD95+T细胞频率增加（平均差异13.3%，P = 0.032）。未发现T细胞或单核细胞亚群之间的其他差异。
肥胖与外周CD4+和CD8+T细胞频率的改变以及CD8+T细胞中CD95表达的异常有关。这些数据表明，CD4+和CD8+T细胞区室以及CD8+T细胞上CD95表达的调节，可作为进一步研究肥胖对免疫系统影响的靶点。
