Li Lin, Li Hai Shan, Pauza C David, Bukrinsky Michael, Zhao Richard Y
Department of Pathology, Institute of Human Virology,University of Maryland, Baltimore, MD 21201, USA.
Cell Res. 2005 Nov-Dec;15(11-12):923-34. doi: 10.1038/sj.cr.7290370.
Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV-infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investigation in this exhilarating area of research.
在1型人类免疫缺陷病毒（HIV-1）感染期间会发生活跃的宿主-病原体相互作用。这些相互作用的结果决定了病毒感染的效率以及随后的疾病进展。HIV感染的细胞会通过各种防御策略来应对病毒入侵，如先天性、细胞性和体液性免疫抗病毒机制。另一方面，病毒也发展出了各种进攻策略来抑制这些宿主细胞反应。在众多病毒进攻策略中，HIV-1病毒辅助蛋白（Tat、Rev、Nef、Vif、Vpr和Vpu）在宿主-病原体相互作用中发挥重要作用，因此对HIV感染的结果有重大影响。其中一个最佳例子是Vif与宿主胞苷脱氨酶APOBEC3G的相互作用。尽管其他辅助蛋白的具体作用不像Vif-APOBEC3G相互作用那样被充分描述，但本简要综述的目的是总结一些初步发现，以期在这个令人兴奋的研究领域激发进一步的讨论和研究。
