Ott David E
AIDS Vaccine Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA.
Rev Med Virol. 2002 Nov-Dec;12(6):359-74. doi: 10.1002/rmv.367.
Human immunodeficiency virus type-1 particles contain host proteins, both on their surface and interior. This review summarises the cellular proteins found in these virions and covers some of their potential roles in the viral life cycle and pathogenesis. For most proteins studied, their role and function are either unknown or in the hypothesis stage. This reflects the relatively recent emphasis given to these proteins by the HIV-1 field as well as the incomplete understanding of their function in the cell. The study of cellular proteins in HIV-1 promises to help us better understand the interaction of this virus with the cell, the immune system, and the whole human host as well as to shed light on the nature of AIDS and suggest more targets for therapeutic intervention. Finally, many of the cell systems themselves are still poorly understood. The extensive study of HIV-1 has already brought increased attention to the fields of immunology and vaccine science and, in the same way, might assist our understanding of the cellular pathways themselves.
1型人类免疫缺陷病毒颗粒在其表面和内部均含有宿主蛋白。本综述总结了在这些病毒粒子中发现的细胞蛋白，并涵盖了它们在病毒生命周期和发病机制中的一些潜在作用。对于大多数所研究的蛋白，其作用和功能要么未知，要么处于假说阶段。这反映出HIV-1领域对这些蛋白的重视相对较新，以及对它们在细胞中功能的理解尚不完整。对HIV-1中细胞蛋白的研究有望帮助我们更好地理解这种病毒与细胞、免疫系统及整个人类宿主之间的相互作用，以及阐明艾滋病的本质并为治疗干预提供更多靶点。最后，许多细胞系统本身仍未被充分了解。对HIV-1的广泛研究已经使免疫学和疫苗科学领域受到更多关注，同样，这可能有助于我们对细胞通路本身的理解。
