Govindarajan Gurushankar, Whaley-Connell Adam, Mugo Maryann, Stump Craig, Sowers James R
University of Missouri-Columbia, School of Medicine, Department of Internal Medicine and Physiology, Harry S. Truman VA Medical Center, Columbia, Missouri 65212, USA.
Am J Med Sci. 2005 Dec;330(6):311-8. doi: 10.1097/00000441-200512000-00009.
The cardiometabolic syndrome (CMS) is associated with cardiovascular disease (CVD) and includes a constellation of risk factors such as central obesity, hypertension, insulin resistance, dyslipidemia, microalbuminuria, and hypercoagulability. Collectively, these risk factors increase CVD endpoints such as stroke, congestive heart failure, chronic kidney disease (CKD), and overall mortality. The CMS is associated with endothelial dysfunction, inflammation, abnormal thrombolysis, and increased oxidative stress that accentuate progression of CVD. We will review how the varying components of the CMS relate to an increased CVD and renal disease risk.
心脏代谢综合征（CMS）与心血管疾病（CVD）相关，包括一系列危险因素，如中心性肥胖、高血压、胰岛素抵抗、血脂异常、微量白蛋白尿和高凝状态。总体而言，这些危险因素会增加CVD终点事件的发生风险，如中风、充血性心力衰竭、慢性肾脏病（CKD）和全因死亡率。CMS与内皮功能障碍、炎症、异常溶栓及氧化应激增加相关，这些会加速CVD的进展。我们将综述CMS的不同组成部分如何与CVD和肾脏疾病风险增加相关。
