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CREB3 蛋白家族：心血管代谢疾病治疗的有潜力靶点。

CREB3 protein family: the promising therapeutic targets for cardiovascular and metabolic diseases.

机构信息

Department of Geriatrics, Hubei Key Laboratory of Metabolic and Chronic Diseases, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Department of Ultrasound, Clinical Research Center for Medical Imaging in Hubei Province, Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

出版信息

Cell Biol Toxicol. 2024 Nov 25;40(1):103. doi: 10.1007/s10565-024-09939-5.

DOI:10.1007/s10565-024-09939-5
PMID:39581923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11586310/
Abstract

Significant advancements in cardiovascular and metabolic disease research have been made with the CREB3 protein family. Studies have revealed that members of this family are crucial in the development of these diseases, contributing to the regulation of lipid metabolism, inflammation, and vascular function. These studies provide useful information for future therapeutic strategies in cardiovascular and metabolic diseases.

摘要

CREB3 蛋白家族在心血管和代谢疾病研究方面取得了重大进展。研究表明，该家族成员在这些疾病的发展中起着至关重要的作用，有助于调节脂代谢、炎症和血管功能。这些研究为心血管和代谢疾病的未来治疗策略提供了有用的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/cc87297017ca/10565_2024_9939_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/6b1f6fba851b/10565_2024_9939_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/02364c760788/10565_2024_9939_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/a513f879af1d/10565_2024_9939_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/f509d16d5219/10565_2024_9939_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/a28c775dc0a3/10565_2024_9939_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/023abd9a9596/10565_2024_9939_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/65dbca59e567/10565_2024_9939_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/8ae27bdbb541/10565_2024_9939_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/875da850b614/10565_2024_9939_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/cc87297017ca/10565_2024_9939_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/6b1f6fba851b/10565_2024_9939_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/02364c760788/10565_2024_9939_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/a513f879af1d/10565_2024_9939_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/f509d16d5219/10565_2024_9939_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/a28c775dc0a3/10565_2024_9939_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/023abd9a9596/10565_2024_9939_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/65dbca59e567/10565_2024_9939_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/8ae27bdbb541/10565_2024_9939_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/875da850b614/10565_2024_9939_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074e/11586310/cc87297017ca/10565_2024_9939_Fig10_HTML.jpg

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本文引用的文献

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Arch Biochem Biophys. 2023 Sep 15;746:109739. doi: 10.1016/j.abb.2023.109739. Epub 2023 Sep 7.
2
ER stress-associated transcription factor CREB3 is essential for normal Ca, ATP, and ROS homeostasis.内质网应激相关转录因子CREB3对正常的钙、三磷酸腺苷和活性氧稳态至关重要。
Mitochondrion. 2023 Mar;69:10-17. doi: 10.1016/j.mito.2023.01.001. Epub 2023 Jan 7.
3
CREBH alleviates mitochondrial oxidative stress through SIRT3 mediating deacetylation of MnSOD and suppression of Nlrp3 inflammasome in NASH.
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Free Radic Biol Med. 2022 Sep;190:28-41. doi: 10.1016/j.freeradbiomed.2022.07.018. Epub 2022 Aug 2.
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Beta-Cell Golgi Stress Response to Lipotoxicity and Glucolipotoxicity: A Preliminary Study of a Potential Mechanism of Beta-Cell Failure in Posttransplant Diabetes and Intraportal Islet Transplant.β细胞高尔基体对脂毒性和糖脂毒性的反应：胰岛移植后门静脉内胰岛移植后β细胞衰竭潜在机制的初步研究。
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Biofactors. 2021 Nov;47(6):964-974. doi: 10.1002/biof.1780. Epub 2021 Sep 9.
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