生命、疾病与医学中的血管生成

Angiogenesis in life, disease and medicine.

作者信息

Carmeliet Peter

机构信息

Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000 Leuven, Belgium.

出版信息

Nature. 2005 Dec 15;438(7070):932-6. doi: 10.1038/nature04478.

DOI:10.1038/nature04478

PMID:16355210

Abstract

The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.

摘要

血管生长（一种被称为血管生成的过程）对于器官生长和修复至关重要。这一过程的失衡会导致多种恶性、炎症、缺血、感染和免疫性疾病。最近，首批抗血管生成药物已被批准用于治疗癌症和失明。血管生成研究可能会在未来几十年改变医学面貌，预计全球超过5亿人将从促血管生成或抗血管生成治疗中受益。