Ferrara Napoleone, Kerbel Robert S
Genentech, 1 DNA Way, South San Francisco, California 94080, USA.
Nature. 2005 Dec 15;438(7070):967-74. doi: 10.1038/nature04483.
Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.
抑制血管生成是治疗癌症和其他几种疾病（包括年龄相关性黄斑变性）的一种有前景的策略。在过去几年中，治疗方面已取得重大进展，并且首批抗血管生成药物最近已在多个国家获批使用。治疗性血管生成（促进新血管生长以治疗缺血性疾病）是心血管医学一个令人兴奋的前沿领域，但首先需要进一步了解血管形态发生的机制。
