Rodríguez Nóvoa Sonia, Barreiro Pablo, Rendón Ana, Barrios Ana, Corral Angélica, Jiménez-Nacher Inmaculada, González-Lahoz Juan, Soriano Vincent
Clinical Pharmacokinetic Unit, Hospital Carlos III, Madrid, Spain.
Clin Infect Dis. 2006 Jan 15;42(2):291-5. doi: 10.1086/499056. Epub 2005 Dec 8.
The 3435C-->T polymorphism at the multidrug resistance gene 1 (MDR1) was examined in 74 patients with human immunodeficiency virus who initiated atazanavir therapy. The MDR1 genotype distribution at position 3435 was 28% CC, 45% CT, and 27% TT. Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations.
在74例开始接受阿扎那韦治疗的人类免疫缺陷病毒患者中，检测了多药耐药基因1（MDR1）的3435C→T多态性。3435位点的MDR1基因型分布为CC型28%、CT型45%、TT型27%。CC基因型患者的阿扎那韦血浆水平显著高于CT或TT基因型患者，且胆红素水平与阿扎那韦浓度相关。
