Palacios R, González M, Ruiz J, Santos Jesús
Servicio de Medicina Interna, Hospital Virgen de la Victoria, Málaga, España.
Enferm Infecc Microbiol Clin. 2008 Dec;26 Suppl 17:41-4. doi: 10.1016/S0213-005X(08)76619-9.
Atazanavir is a drug that inhibits HIV protease. It has many of the characteristics of other protease inhibitors and also some advantages over these, such as the single dose of once per day, low capsule load, less gastrointestinal problems and a very friendly metabolic profile, including carbohydrate metabolism. Secondary high plasma bilirubin and jaundice are its main adverse effect which only on rare occasions requires stopping the drug. Other adverse effects, such as nephrolithiasis or ECG changes are extremely rare.
阿扎那韦是一种抑制HIV蛋白酶的药物。它具有许多其他蛋白酶抑制剂的特性，并且相对于这些抑制剂还有一些优势，例如每日单次给药、胶囊服用量少、胃肠道问题较少以及包括碳水化合物代谢在内的非常良好的代谢特征。继发性高血浆胆红素和黄疸是其主要不良反应，仅在极少数情况下需要停药。其他不良反应，如肾结石或心电图改变极为罕见。
