蛋白酶激活受体-2激动剂SLIGRL-NH2诱导的小鼠抓挠行为
Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2.
作者信息
Shimada Steven G, Shimada Kelly A, Collins J G
机构信息
Department of Anesthesiology, Yale University School of Medicine, P.O. Box 208051, 333 Cedar Street, New Haven, CT 06520-8051, USA.
出版信息
Eur J Pharmacol. 2006 Jan 20;530(3):281-3. doi: 10.1016/j.ejphar.2005.11.012. Epub 2005 Dec 13.
We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 microg) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals with a histamine H1 receptor antagonist, pyrilamine, blocked histamine induced scratching, but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates histamine independent itch.
我们研究了蛋白酶激活受体-2（PAR2）激动剂H-Ser-Leu-Ile-Gly-Arg-Leu-NH2（SLIGRL-NH2）是否能诱导小鼠出现抓挠行为。皮内注射SLIGRL-NH2（10 - 50微克）可引起剂量依赖性抓挠。这种行为在5分钟左右达到峰值，并在30分钟内恢复到注射前水平。用组胺H1受体拮抗剂吡苄明对动物进行预处理，可阻断组胺诱导的抓挠，但对SLIGRL诱导的抓挠影响很小。我们的研究表明，PAR2介导不依赖组胺的瘙痒。
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