Tsujii Kenichiro, Andoh Tsugunobu, Lee Jung-Bum, Kuraishi Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
J Pharmacol Sci. 2008 Nov;108(3):385-8. doi: 10.1254/jphs.08200sc. Epub 2008 Nov 6.
Proteinase-activated receptor-2 (PAR2) participates in itch, but the role of the other subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-related behavior, was observed following intradermal injections of the activating peptides of PAR1-4 in mice. Activating peptides of PAR1, PAR2, and PAR4, but not PAR3, induced scratching. The antihistamine terfenadine suppressed scratching elicited by activating peptides of PAR1 and PAR4, but not PAR2. These results suggest that PAR1, PAR2, and PAR4 are involved in itch and that histamine is a cause of itch related to PAR1 and PAR4, but not PAR2.
蛋白酶激活受体-2（PAR2）参与瘙痒过程，但该受体其他亚型的作用尚不清楚。为了研究这个问题，在小鼠皮内注射PAR1-4的激活肽后，观察了搔抓这一与瘙痒相关的行为。PAR1、PAR2和PAR4的激活肽可诱发搔抓，而PAR3的激活肽则不能。抗组胺药特非那定可抑制PAR1和PAR4激活肽引起的搔抓，但不能抑制PAR2激活肽引起的搔抓。这些结果表明，PAR1、PAR2和PAR4参与瘙痒，且组胺是与PAR1和PAR4相关的瘙痒原因，但不是PAR2相关瘙痒的原因。
